For those who may have tried other variants... is there a big difference between Ozempic/Wegovy/Mounjaro? My doctor prescribed WeGovy but my insurance does not cover it - my spouses does. However Mounjaro is covered by both insurances. Is it worth (effectiveness) switching to Mounjaro? I heard it is a 'double agonist' - what exactly does that mean?
I am also reading up on things called triple agonist but its not readily available in Canada. Web sites with a lot of discussion about peptides and titrating which seems a little difficult.
I've lost 28 lbs on Mounjaro in about 3-4 months. One injection per week, self-administered, completely painless. No more 6-8pm food cravings. That's on top of the money I save vs. eating out all the time (maybe $500-600 per month, vs. $800 every 6 months for the medicine itself, without insurance). YMMV if you cook at home a lot, but I consider it one of the best lifestyle decisions I've made in recent memory.
It totally solved my food addiction. It flipped it like a switch - I knew what most people are like, where food isn't a thought every 15 minutes. What a glorious time. So much free head space
It is now firmly back, after ~6 months off the drug (due to cost) :/
I've managed to keep off the lost weight, through a lot of willpower, but winter will be a struggle I can tell.
I'm curious if you've tried any methods to increase your endogenous GLP-1 activity?
These include things like loading your body earlier in the day with heavy protein and fermented foods, eating proteins and vegetables before carbs (make less room for carbs), and of course there is still the lower stress, improve sleep and exercise.
I'm not suggesting these are replacements, but potentially like a micro-dose response.
I did try keto before. Heavy protein, low carbs. Everyone promised a high protein/fat/fiber diet with low starch/sugar was the secret to feeling full sooner and for longer.
Nope. Didn't change a damn thing. I was still hungry all the time.
It wasn't until this week that I started feeling the effect, and so far, it's like...yeah. I don't feel this damn near constant urge to eat anymore.
It's so frustrating to deal with people who naturally eat sensibly and look down on overweight people and accuse them of not having self-control. They have a complete lack of empathy and assume that everyone else has the same properly-calibrated sense of hunger that they do. Guess what: not everyone does.
They have no idea what it's actually like. They'll eat a six-inch sub sandwich and feel full all the way to dinner. Maybe they'll eat a handful of nuts in the afternoon if they get snackish. Then they assume that's what life is like for me.
No. If I ate just the six-inch sandwich, my stomach wouldn't even tell me I'm satiated, let alone full. I'd have to eat the footlong. And I'd still be hungry two hours later. Yeah, I'd eat a handful of nuts. And then another. And another. Until eventually I've eaten 700+ calories from nuts and I'd still be fucking hungry.
And don't tell me "drink more water!". If anything, I was overhydrating. My urine was nearly clear and I'm pissing every hour.
Ozempic has flipped the switch, though admittedly I'm in a transition period for sure. I went out for dinner the other day, had a bowl of soup and only about 1/3rd of my main course. My stomach was feeling full, but something was still telling me to keep eating. Luckily the discomfort of fullness won out and I took the rest home. The next day, for lunch, I ate the leftovers, and I felt full afterwards, and didn't feel the urge to snack at all before dinner.
It's such a breath of fresh air. Is this what normal or "naturally thin" people experience? Hunger that reflects actual caloric needs, rather than some unnecessary urge to constantly keep adding things to the stomach?
EDIT: "It is now firmly back, after ~6 months off the drug (due to cost) :/"
That sucks. With my insurance, it's only $50 for a 4-week supply, but on the prescription form from Costco, it lists the "U/C" as $2,207, which my understanding means it would be $2,207 if I didn't have insurance.
This may or may not have worked for you but I’ve found a lot of people just don’t give their bodies enough time to adjust to caloric deficit, it takes a couple weeks.
If you ever tried water fasting first couple of days are gruelling but day 3 and 4 are significantly easier. Another natural hunger suppressant is cardio which reduces hunger.
If a molecule can downregulate (downmodulate?) cravings so effectively, could there be a molecule that does the opposite?
This is basically about as far as I feel like entertaining conspiracy theories. I think it's a fairly grounded one, compared to most.
Not claiming that a molecule or a class of such molecules (or a perfect storm of unrelated molecules acting indirectly) is behind the obesity epidemic, or that there's explicit malicious intention involved, just that it does make me wonder.
These drugs are a godsend for so many (me included, on retatrutide) but especially for those of us here in America - legal environment broad enough to get them, relatively wealthy enough to afford them, and notably fat enough to benefit from them. The diffusion of this technology through the US might well increase American lifespan in a notable way.
Now all we need is an easy pill that makes you hate opioids.
I am also reading up on things called triple agonist but its not readily available in Canada. Web sites with a lot of discussion about peptides and titrating which seems a little difficult.
It is now firmly back, after ~6 months off the drug (due to cost) :/
I've managed to keep off the lost weight, through a lot of willpower, but winter will be a struggle I can tell.
These include things like loading your body earlier in the day with heavy protein and fermented foods, eating proteins and vegetables before carbs (make less room for carbs), and of course there is still the lower stress, improve sleep and exercise.
I'm not suggesting these are replacements, but potentially like a micro-dose response.
I did try keto before. Heavy protein, low carbs. Everyone promised a high protein/fat/fiber diet with low starch/sugar was the secret to feeling full sooner and for longer.
Nope. Didn't change a damn thing. I was still hungry all the time.
My experience mirrors the GP. Ozempic really flipped the switch. See my other comment (https://news.ycombinator.com/item?id=50399564) for more.
It wasn't until this week that I started feeling the effect, and so far, it's like...yeah. I don't feel this damn near constant urge to eat anymore.
It's so frustrating to deal with people who naturally eat sensibly and look down on overweight people and accuse them of not having self-control. They have a complete lack of empathy and assume that everyone else has the same properly-calibrated sense of hunger that they do. Guess what: not everyone does.
They have no idea what it's actually like. They'll eat a six-inch sub sandwich and feel full all the way to dinner. Maybe they'll eat a handful of nuts in the afternoon if they get snackish. Then they assume that's what life is like for me.
No. If I ate just the six-inch sandwich, my stomach wouldn't even tell me I'm satiated, let alone full. I'd have to eat the footlong. And I'd still be hungry two hours later. Yeah, I'd eat a handful of nuts. And then another. And another. Until eventually I've eaten 700+ calories from nuts and I'd still be fucking hungry.
And don't tell me "drink more water!". If anything, I was overhydrating. My urine was nearly clear and I'm pissing every hour.
Ozempic has flipped the switch, though admittedly I'm in a transition period for sure. I went out for dinner the other day, had a bowl of soup and only about 1/3rd of my main course. My stomach was feeling full, but something was still telling me to keep eating. Luckily the discomfort of fullness won out and I took the rest home. The next day, for lunch, I ate the leftovers, and I felt full afterwards, and didn't feel the urge to snack at all before dinner.
It's such a breath of fresh air. Is this what normal or "naturally thin" people experience? Hunger that reflects actual caloric needs, rather than some unnecessary urge to constantly keep adding things to the stomach?
EDIT: "It is now firmly back, after ~6 months off the drug (due to cost) :/"
That sucks. With my insurance, it's only $50 for a 4-week supply, but on the prescription form from Costco, it lists the "U/C" as $2,207, which my understanding means it would be $2,207 if I didn't have insurance.
The price of this drug is damn near criminal.
If you ever tried water fasting first couple of days are gruelling but day 3 and 4 are significantly easier. Another natural hunger suppressant is cardio which reduces hunger.
This is basically about as far as I feel like entertaining conspiracy theories. I think it's a fairly grounded one, compared to most.
Not claiming that a molecule or a class of such molecules (or a perfect storm of unrelated molecules acting indirectly) is behind the obesity epidemic, or that there's explicit malicious intention involved, just that it does make me wonder.
Now all we need is an easy pill that makes you hate opioids.